Mechanisms Of Drug Resistance Concept Map

Bacillus streptomyces penicillium cephalosporium.

Mechanisms of drug resistance concept map. Their chemical basis and effects stable heritable changes in sequence of bases in dna point mutations most common from alteration of single pairs of nucleotide from the addition or deletion of nucleotide pairs larger mutations are less common insertions deletions inversions. A review of drug resistance in cancer analyses each biological determinant of resistance separately and discusses existing and new therapeutic strategies to combat the problem as a whole. Those usually map to the target of the drug and then that tells you what the drug is. The traditional way of figuring out how an antibiotic works is to find resistance mutants.

1 00 points move the correct terms into their corresponding empty boxes within the figure to complete the concept map. Construct a table concept map or picture to summarize how base analogues dna modifying agents and intercalating agents cause mutations 3. Drug can t bind its target drug precipitates drug inactivation drug enters but doesn t stay drug enhancement mechanisms of drug resistance in which drug is changed decreased permeability in which drug binding site altered in which drug pumps in which alternate metabolic pathway drug binds correctly. Receptors are lower in number or affinity for drug drug inactivation drug enters but doesn t stay synthesis occurs by other patterns drug precipitates mechanisms of drug resistance in which drug is altered by enzymes decreased permeability in which drug binding site altered in which drug pumps in which alternate metabolic pathway reset receptors are lower in number or.

Bacillus streptococcus streptomyces penicillium cephalosporium staphylococcus. First several strategies rely on model organisms that are compatible with genetic manipulations 1 3 however many drugs are inactive in these organisms possibly due to multi drug resistance mechanisms and target divergence 4 second affinity based methods are used to identify proteins that bind the drug 5 6 these approaches are effective when the drug is potent and the targets are reasonably abundant in vivo. In this case. Label the image to assess your understanding of the five major mechanisms of antimicrobial resistance top the drug is inactivated by an enzyme the receptor that transported the drug is altered so that the drug can not enter the cell specialized membrane proteins are activated and continually pump the drug out to the cell binding cite on target ribosome is altered so drug has no affect the drug has blocked the usual metabolic pathways so an alternate unblocked pathway is used.

Mechanisms of anticancer drugs resistance. Article pdf available january 2012 with 3 358 reads how we measure reads a read is counted each time someone views a publication. Move the correct terms into their corresponding empty boxes within the figure to complete the concept map. Receptors are lower in number or affinity for drug drug enters but doesn t stay synthesis occurs by other patterns.

Select the five major. Move the terms into the correct empty boxes to complete the concept map. Currently approaches to analyze how a drug works fall into two broad categories.